Effects of Probiotics and Nutritional Status on Exercise-Induced Symptoms, and Endurance Performance in Ultra-Endurance Athletes
- Conditions
- Ultra-endurance Athletes With Gastrointestinal Symptoms
- Interventions
- Dietary Supplement: Oral Rehydration Salts onlyDietary Supplement: Oral Rehydration Salts supplemented with L. Rhamnosus GG
- Registration Number
- NCT04779281
- Lead Sponsor
- Istanbul Medeniyet University
- Brief Summary
Ultra-endurance athletes have been commonly endured extreme conditions during races and training sessions, resulting in exercise-associated clinical symptoms, including gastrointestinal symptoms, dehydration, and elevated oxidative stress. Although these alterations adversely affect sports performance and well-being, there is no certain treatment or consensus on alleviating the exercise-associated clinical symptoms in ultra-endurance athletes. The objective of this study is to determine the effects of oral rehydration salts supplemented with Lactobacillus Rhamnosus GG on exercise-induced gastrointestinal problems, dehydration and oxidative stress in ultra-endurance athletes. Additionally, we aimed to assess the exercise-induced alterations in oxidative stress determined by applying an acute strenuous exercise protocol ((a cycle ergometer (45 min at 65%VO2max) immediately followed by a treadmill test (75% VO2max to exhaustion)) before and after the supplementation period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 24
- Participants who train at least 15 h per week,
- Participants who do not have any metabolic disease,
- Have had at least one gastrointestinal symptom determined by using a Gastrointestinal Symptoms Rating Scale and Bristol Stool Chart Form Scale,
- Being a non-smoker,
- Have participated in at least one ultra-endurance race/event (lasts > 4 hr),
- Taking no vitamins, minerals, dietary supplements, antibiotics, and any medication at least during the three months before the study,
- (For women) participants with a regular menstrual cycle of physiological length (24-35 days)
- Regular tobacco use
- Inability to adhere to any of the study protocol requirements (i.e. alcohol, caffeine consumption, diet control)
- Having consumed any supplements and/or medicines for the preceding 3 months period.
- (For women) participants in menopause or using oral contraceptives
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oral Rehydration Salts supplemented with L. Rhamnosus GG Oral Rehydration Salts only a supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, Lactobacillus Rhamnosus GG ATC53103 HN019 strain and fructooligosaccharides Oral Rehydration Salts only Oral Rehydration Salts supplemented with L. Rhamnosus GG A supplement containing sodium chloride, trisodium citrate, potassium chloride, dextrose, microcrystalline cellulose
- Primary Outcome Measures
Name Time Method Changes of the gut microbiome after a 4-week supplementation period Change from Baseline Gut Microbiome at 4 weeks - To assess the profile of gut flora (% abundance of various bacterial phyla, families, genera and species) at baseline and after supplementation in ultra-endurance athletes, using a 16S ribosomal RNA sequencing
- Secondary Outcome Measures
Name Time Method Changes in blood markers of exercise-associated oxidative stress (8-isoprostaglandin 2Fa, Total Antioxidant Capacity, and Total Oxidant Capacity in plasma) 4 weeks - Blood samples were collected pre-and post-exercise applied before and after supplementation to evaluate the change in exercise-induced oxidative stress in plasma. Plasma concentrations of 8-isoprostaglandin 2Fa, Total Antioxidant Capacity, and Total Oxidant Capacity were analysed using ELISA kits.
Trial Locations
- Locations (1)
Centre of Athlete Training and Health Research
🇹🇷Ankara, Turkey
Centre of Athlete Training and Health Research🇹🇷Ankara, Turkey