Effects of Nutritional Status and Probiotics on Exercise-Related Clinical and Gastrointestinal Symptoms and Endurance Performance in Ultra-Endurance Athletes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Changes of the gut microbiome after a 4-week supplementation period
研究概览
简要总结
Ultra-endurance athletes have been commonly endured extreme conditions during races and training sessions, resulting in exercise-associated clinical symptoms, including gastrointestinal symptoms, dehydration, and elevated oxidative stress. Although these alterations adversely affect sports performance and well-being, there is no certain treatment or consensus on alleviating the exercise-associated clinical symptoms in ultra-endurance athletes. The objective of this study is to determine the effects of oral rehydration salts supplemented with Lactobacillus Rhamnosus GG on exercise-induced gastrointestinal problems, dehydration and oxidative stress in ultra-endurance athletes. Additionally, we aimed to assess the exercise-induced alterations in oxidative stress determined by applying an acute strenuous exercise protocol ((a cycle ergometer (45 min at 65%VO2max) immediately followed by a treadmill test (75% VO2max to exhaustion)) before and after the supplementation period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants who train at least 15 h per week,
- •Participants who do not have any metabolic disease,
- •Have had at least one gastrointestinal symptom determined by using a Gastrointestinal Symptoms Rating Scale and Bristol Stool Chart Form Scale,
- •Being a non-smoker,
- •Have participated in at least one ultra-endurance race/event (lasts > 4 hr),
- •Taking no vitamins, minerals, dietary supplements, antibiotics, and any medication at least during the three months before the study,
- •(For women) participants with a regular menstrual cycle of physiological length (24-35 days)
排除标准
- •Regular tobacco use
- •Inability to adhere to any of the study protocol requirements (i.e. alcohol, caffeine consumption, diet control)
- •Having consumed any supplements and/or medicines for the preceding 3 months period.
- •(For women) participants in menopause or using oral contraceptives
结局指标
主要结局
Changes of the gut microbiome after a 4-week supplementation period
时间窗: Change from Baseline Gut Microbiome at 4 weeks
- To assess the profile of gut flora (% abundance of various bacterial phyla, families, genera and species) at baseline and after supplementation in ultra-endurance athletes, using a 16S ribosomal RNA sequencing
次要结局
- Changes in blood markers of exercise-associated oxidative stress (8-isoprostaglandin 2Fa, Total Antioxidant Capacity, and Total Oxidant Capacity in plasma)(4 weeks)
研究者
Asli Devrim Lanpir
Research Assistant, PhD
Istanbul Medeniyet University