Effects of anesthesia on neural mechanisms of pain processing and pain-related memories

Not Applicable

Recruiting

Conditions: Young healthy male and female participants

Registration Number: DRKS00033620

Lead Sponsor: Abteilung für Medizinische Psychologie und Medizinische Soziologie

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 75

Inclusion Criteria

Physical status classification ASA PS1 according to the American Society of Anesthesiologists; BMI 18-30 kg/m2.

Exclusion Criteria

MRI-relevant factors (e.g. claustrophobia, metallic implants, etc.); any physical or mental illness; regular use of medication; indications of substance abuse including nicotine and alcohol; indications of a difficult airway (according to the airway checklist), allergies to propofol and remifentanil as well as to soy, peanuts and egg; suspected anesthesia-associated diseases (e.g. malignant hyperthermia) or assessment by the anesthesiologist for increased anesthesiological risk; changes in the anorectal area; pregnancy or breastfeeding; oral contraception.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eural activation assessed via functional magnetic resonance imaging (fMRI) in response to acoustic conditioned cues and visceral pain stimuli; VAS ratings of stimulus intensity, valence and fear of pain and pain-predictive acoustic signals

Secondary Outcome Measures

Name	Time	Method
Functional and structural brain connectivity (diffusion tensor imaging, DTI; resting state functional magnetic resonance imaging, rsfMRI); questionnaires; ratings regarding memories of intensity, valence, contingency and fear; immunological analysis parameters from blood samples