The effect of spinal anesthesia on pain perception and sedation in healthy volunteers

Completed

• Conditions: (chronische) neuropathische pijn; chronic pain; neuropathic pain; 10034606

• Registration Number: NL-OMON38807
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

Healthy male volunteers, aged 18 to 45 years, right-handed.

Exclusion Criteria

- Obesity (BMI > 30);
- Significant history of any cardiac or vascular disorder, asthma or other pulmonary disease, major gastrointestinal abnormalities, peptic ulceration, hepatic, neurological, psychiatric, hematological (including bleeding disorders), endocrine, renal, or major genitourinary disease;
- History of illness, condition or medication use that, in the opinion of the investigator, might interfere with optimal participation, confound the results of the study or pose additional risk in administering spinal anesthesia to the subject;
- History of chronic alcohol or illicit drug use;
- Metal medical devices like pacemakers, knee or hip prosthesis, ear implants, vessel clips, subcutaneous insulin pumps or carries metal particles (e.g. metal splinter in the eye) inside the body;
- Claustrophobia;
- Allergy to study medications;
- Not able to maintain a regular diurnal rhythm.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>fMRI measures (BOLD signal)<br /><br>pain intensity (VAS)in response to a noxious thermal stimulus<br /><br>reaction time after a cognitive test</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.v.t.</p><br>