Factors Influencing Risk of Progression of Chronic Kidney Disease in Patients With Severe Renal Failure

Centre Hospitalier Universitaire de Besancon1 site in 1 country1,300 target enrollmentApril 9, 2012

ConditionsChronic Kidney Disease stage4

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Chronic Kidney Disease stage4
Sponsor: Centre Hospitalier Universitaire de Besancon
Enrollment: 1300
Locations: 1
Primary Endpoint: Evolution of estimated Glomerular Filtration Rate (GFR) according to MDRD equation (modification of diet in renal disease) at each visit
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to identify typical patterns of renal function evolution in patients with stage 4 chronic kidney disease, regularly followed in nephrology consultation and included in a French cohort.

Registry

clinicaltrials.gov

Start Date

April 9, 2012

End Date

December 31, 2018

Last Updated

6 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Centre Hospitalier Universitaire de Besancon

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients meeting the inclusion criteria of the ND-CRIS cohort (long-term follow-up in one of the centers participating in the research, with a GFR \<60mL/min /1.73m2)
•Patients included in the ND-CRIS cohort on the date when the estimate of their GFR is strictly less than 30mL/min/1.73m2 and greater than or equal to 15mL/min/1.73m2 (MDRD equation).
•Patients should have at least two measurements of GFR \<30mL/min/1.73m2 to be included, at least one of them greater than or equal to 15mL/min/1.73m
•The date of the first GFR \<30mL/min/ 1.73m2 will be considered as the date of origin.

Exclusion Criteria

•Patients with GFR ≥30mL / min / 1.73m2 or \<15mL / min / 1.73m2
•Patients who do not meet the inclusion criteria of ND-CRIS cohort (dialysis patients, transplant patients, unfollowed patients)

Outcomes

Primary Outcomes

Evolution of estimated Glomerular Filtration Rate (GFR) according to MDRD equation (modification of diet in renal disease) at each visit

Time Frame: up to 3 years

Time between inclusion and occurrence of the "progression" event

Time Frame: up to 3 years

progression: initiation of an extra-renal purification technique or reduction of GFR of at least 5 mL / min / 1.73m2 compared to inclusion in FAIR-PROGRESS