Glutamatergic Modulation of Motivation Enhancement: A Pilot Feasibility Trial
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Cocaine Use
研究概览
简要总结
This study evaluates the feasibility of a treatment paradigm that involves naturalistic cocaine use opportunities in the context of psychotherapy aimed at utilizing these opportunities therapeutically.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
open-label
52 minute infusion of NMDA antagonist
干预措施: infusion of NMDA antagonist (Drug)
结局指标
主要结局
Cocaine Use
时间窗: 5 weeks
Participants were provided choices to use up to 5 hits of cocaine on up to 2 occasions (cocaine versus money). Participants who chose cocaine (1 or more hits) during the first choice opportunity are administered a 52 minute infusion of 0.71 mg/kg ketamine the following day. Another choice opportunity occurs 24 hours later. The primary outcome is the choice participants made during these occasions
次要结局
未报告次要终点
研究者
Elias Dakwar
Assistant Professor of Clinical Psychiatry
New York State Psychiatric Institute