Impact of "No-touch" Technique on the Outcome of Liver Transplantation for Hepatocellular Carcinoma
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 800
- Primary Endpoint
- Recurrence free surviavl rate
Study Overview
Brief Summary
The "no-touch" technique has been one of the most important principles of oncological surgery and aimed to prevent seeding and tumor cell dissemination. Previous studies in hepatectomy have shown that no-touch technique surgery can reduce HCC recurrence and improve the survival of patients. However, there is no consensus on whether the no-touch technique in LT for HCC improves the outcomes. This study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant clinical information, post-transplant pathological records and exploring and clarify the correlation between "no-touch" technique and the prognosis of LT patients.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Diagnosis of HCC based on CT or MRI imaging or needle biopsy confirming a histologic diagnosis of HCC.
- •Patients undergoing deceased donor liver transplantation for the first time.
Exclusion Criteria
- •(1) patients who received split LT or simultaneous transplantation, (2) patients who received re-transplantation, (3) patients with macroscopic portal vein tumor thrombosis or other macrovascular invasion, (4) patients with incomplete follow-up or incomplete important parameters records.
Outcomes
Primary Outcomes
Recurrence free surviavl rate
Time Frame: 2024.4.1-2028.4.1
Overall survival rate
Time Frame: 2024.4.1-2028.4.1
Tumor recurrence rate
Time Frame: 2024.4.1-2028.4.1
Secondary Outcomes
No secondary outcomes reported
Investigators
Xiao Xu
Professor
Zhejiang University