Hepatic Artery Stenosis and Thrombosis After Liver Transplantation in Children: a Multicenter, Retrospective, Observational Study

University Medical Center Groningen1 site in 1 country400 target enrollmentSeptember 28, 2023

ConditionsHepatic Artery Thrombosis Hepatic Artery Stenosis Pediatric ALL Liver Transplant; Complications

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Hepatic Artery Thrombosis
Sponsor: University Medical Center Groningen
Enrollment: 400
Locations: 1
Primary Endpoint: Graft survival
Status: Enrolling By Invitation
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this observational study is to investigate the incidence, current management practices, and outcomes in pediatric patients with HAC after liver transplantation.

Research question:

What are the overall incidence of HAC and the effectiveness of all treatment strategies for HAC after pediatric LT?
What are the current management practices in the experience of centers, anticoagulant therapy, screening protocol, and assessment criteria for HAC after pediatric LT?

The burden of participation is considered to be minimal, and limited to the questionnaires.

Registry

clinicaltrials.gov

Start Date

September 28, 2023

End Date

December 2025

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

University Medical Center Groningen

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Graft survival

Time Frame: 1-1-2001 and 1-1-2023

Graft survival is defined as a functioning graft from transplantation to the end of follow-up data, re-transplantation, or death, whichever occurs first.

Patient survival

Time Frame: 1-1-2001 and 1-1-2023

Patient survival is defined from the date of the primary LT until date of death. Causes of re-transplantation or death will be recorded.

Secondary Outcomes

Incidence(1-1-2001 and 1-1-2023)
Technical success(1-1-2001 and 1-1-2023)
Intra- and post-procedural complications(1-1-2001 and 1-1-2023)
Primary and secondary patency(1-1-2001 and 1-1-2023)
Anticoagulant therapy after transplantation and after interventions(1-1-2001 and 1-1-2023)
Center specific screening protocol(1-1-2001 and 1-1-2023)
Center specific diagnostic criteria(1-1-2001 and 1-1-2023)
Center specific radiological follow up(1-1-2001 and 1-1-2023)