NL-OMON51756招募中2 期
Metabolic effects of ketohexokinase inhibition in individuals with non-alcoholic fatty liver disease - KHKi in NAFLD
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 入组人数
- 17
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •-Men and (postmenopausal) woman
- •-Age: >= 40 and <= 75 years
- •-BMI: 27-38 kg/m2
- •-Hepatic steatosis (i.e. IHL content >= 5.56%)
- •-Stable dietary habits (no weight loss or gain >3 kg in the 3 months prior to
- •-Participants are able to provide signed and dated written informed consent
- •prior to any study specific procedures
排除标准
- •-Type 2 diabetes
- •-Any contra-indication for MRI scanning
- •-Patients with congestive heart failure and and/or severe renal and/or liver
- •insufficiency
- •-Uncontrolled hypertension
- •-Alcohol consumption of >3 servings per day for man and >2 servings per day for
- •-Unstable body weight (weight loss or gain >3 kg in the 3 months prior to
- •-Engagement in structured exercise activities > 2 hours a week
- •-Previous enrolment in a clinical study with an investigational product during
- •the last 3 months or as judged by the Investigator which would possibly hamper
- •our study results
- •-Use of drugs that inhibit organic anion transporting polypeptide (OATP)
- •transporters (e.g. rifampicin, gemfibrozil, cyclosporine, erythromcyin and
- •clarithromycin)
- •-Subjects who do not want to be informed about unexpected medical findings
研究者
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