Registry of female precocious puberty, aiming identification of predisposing factors, optimization of treatment strategy, and elucidation of prognosis
Not Applicable
Recruiting
- Conditions
- female central precocious puberty
- Registration Number
- JPRN-UMIN000044400
- Lead Sponsor
- Showa University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1) premature thelarche 2) central precocious puberty with organic origin 3) gonadotropin-independent precocious puberty
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Information collected at the time of diagnosis: family history, maternal information during pregnancy, perinatal history, past history, social history, growth data, physical findings, endocrine test (LH, FSH, E2, DHEA-S, TSH, Free T3, Free T4, IGF-1), Bone age, ultrasonic findings of uterus and ovary, MRI findings in hypothalamo-pituitary region 2) Information collected during follow-up or treatment For non-treatment patients: growth data, physical findings, bone age (every 6 months to 1 year until menarche) For patients with LHRH analog treatment: growth data, physical findings, endocrine test, bone age, ultrasonic findings, treatment details 3) Information to be collected after the completion of treatment growth data, physical findings, endocrine tests, ultrasonography (6-months and one year following the cessation)
- Secondary Outcome Measures
Name Time Method Serum will be cryopreserved for each patient.