Kisspeptin/GPR54 Pathway and Early Puberty

Completed

• Conditions: Puberty, Precocious
• Interventions: Other: this study was an observational study and no interventions were given to the participants

• Registration Number: NCT04012632
• Lead Sponsor: Shenzhen Center for Disease Control and Prevention

Brief Summary

There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study was designed to explored the association of polymorphisms in KISS1/GPR54 pathway genes and the risk of early puberty in Chinese Han girls.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09-01
• Primary Completion: 2018-05-20
• Status Verified: 2019-07
• Study Completion: 2019-07-04
• Study First Submitted: 2019-07-05
• Study First Submitted QC: 2019-07-05
• Study First Posted: 2019-07-09
• Last Update Submitted: 2019-07-09
• Last Update Posted: 2019-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 628

Inclusion Criteria

• Clinical diagnosis of central precocious puberty or early and fast puberty.

Exclusion Criteria

• The participants who were not the first visit to the hospital and had been treated before.
• The participants who were with endocrine disorders.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
controls	this study was an observational study and no interventions were given to the participants	Controls were matched to cases at 1:1 by age (± 3 months)

Primary Outcome Measures

Name	Time	Method
the polymorphism in the KISS1/GPR54 pathway genes	3 months	functional SNP loci of the KISS1/GPR54 pathway genes KISS1, KISSIR, PLCB1, PRKCA, and ITPR1 were selected and detected.