Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: 3 ounces of cooked, 85% lean ground beef; Dietary Supplement: 20 grams beef protein isolate

• Registration Number: NCT01415973
• Lead Sponsor: University of Arkansas

Brief Summary

This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.

Detailed Description

STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.

Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2011-08-10
• Study First Submitted QC: 2011-08-11
• Study First Posted: 2011-08-12
• Primary Completion: 2011-09
• Status Verified: 2012-01
• Study Completion: 2012-01
• Last Update Submitted: 2012-01-17
• Last Update Posted: 2012-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy male or female.
• Age 60 years or older.

Exclusion Criteria

• Any (history of) gastrointestinal disease that interferes with GI function
• Diagnosed and active treatment of Diabetes Mellitus type I or II
• History of congestive heart failure
• Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
• Myocardial infarction in the past year
• Infection or fever in the 7 days prior to enrollment
• Current use of corticosteroids, growth hormone, or testosterone
• Adherence to a weight loss diet
• Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
• Current alcohol (>7 ETOH per week) or drug abuse
• Platelet count (PLT) < 100,000
• History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
• Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
• Allergy to local anesthetic
• Blood hemoglobin < 9.0 g/dL
• Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
3 ounces of cooked, 85% lean ground beef	3 ounces of cooked, 85% lean ground beef	Subjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.
20 grams of Beef protein isolate	20 grams beef protein isolate	Subjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.

Primary Outcome Measures

Name	Time	Method
skeletal muscle synthetic and breakdown rate	day one	Using stable isotope infusion/ingestion methodology, we will measure plasma and skeletal muscle metabolic rate. Our primary end points will be muscle protein fractional synthesis rate (FSR) and whole body protein turnover rate.

Secondary Outcome Measures

Name	Time	Method
concentrations of plasma amino acids, insulin and glucose	day one	Secondary endpoints are concentrations of plasma amino acids, insulin and glucose.

Trial Locations

Locations (1)

UAMS Center on Aging; 🇺🇸 Little Rock, Arkansas, United States