The Impact of Beef on Muscle Fatigue in Older Adults

Not Applicable

Recruiting

• Conditions: Muscle; Fatigue, Heart; Muscle Weakness; Older Adults
• Interventions: Other: Vegetarian Diet; Other: Beef Diet

• Registration Number: NCT05860088
• Lead Sponsor: Indiana University

Brief Summary

The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are:

AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet.

AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue.

Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-04-25
• Study First Submitted QC: 2023-05-05
• Study First Posted: 2023-05-16
• Study Start: 2023-07-10
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-07
• Last Update Posted: 2024-02-09
• Primary Completion: 2024-12
• Study Completion: 2024-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Vegetarian Diet	Vegetarian Diet	Participants will be randomized to consume the vegetarian diet for 8 weeks. After a 2-week period, participants will cross-over to consume the beef diet for 8 weeks.
Beef Diet	Beef Diet	Participants will be randomized to consume the beef diet for 8 weeks. After a 2-week period, participants will cross-over to consume the vegetarian diet for 8 weeks.

Primary Outcome Measures

Name	Time	Method
Change in 6-minute walk	Weeks 0, 4, 8	The change in muscle strength observed in each diet condition will be evaluated through the 6-Minute-Walk-Test. The distance walked by a participant during the 6 minute test period will be recorded.
Adherence to Study Diets	Through study completion, approximately 16 weeks	Participant adherence to the study diets will be evaluated.
Change in Sit-to-Stand Chair Test	Weeks 0, 4, 8	The change in muscle strength observed in each diet condition will be evaluated through the Sit-To-Stand Chair Test. The number of times a participant comes to a full standing position (from a seated position) in 60 seconds will be recorded.
Retention of Participants	Through study completion, approximately 16 weeks	The percentage of randomized participants completing the 16-week diet intervention trial.

Secondary Outcome Measures

Name	Time	Method
Change in Amino Acids	Weeks 0, 4, 8	Measures of muscle fatigue will be evaluated through blood biomarkers.
Change in Lactate	Weeks 0, 4, 8	Measures of muscle fatigue will be evaluated through blood biomarkers.
Change in Carnosine	Weeks 0, 4, 8	Measures of muscle fatigue will be evaluated through blood biomarkers.
Change in Beta-Alanine	Weeks 0, 4, 8	Measures of muscle fatigue will be evaluated through blood biomarkers.

Trial Locations

Locations (1)

Indiana University Bloomington; 🇺🇸 Bloomington, Indiana, United States