The Effect of Sleep Quality on Coronary Artery Disease and In Stent Restenosis
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 958
- Locations
- 1
- Primary Endpoint
- In-stent restenosis
Study Overview
Brief Summary
This is a cross-sectional and follow-up study. We analysis the relationship of sleep quality on coronary artery disease(CAD) and in stent restenosis(ISR). Further, we explore the mechanism of relationship between the sleep quality and CAD/ ISR by examining the biomarkers in the pathway of sleep-CAD/ISR.
Detailed Description
Background: Coronary artery disease (CAD) is the leading cause of mortality in the world. The important treatment of CAD is Percutaneous coronary intervention(PCI). However, in-stent-restenosis(ISR) is the major issue in the PCI. The factors of ISR include gender, age, diabetes, lipid ,obesity and so on.Recently, studies showed that sleep duration and sleep quality have effect on all of factors and have relationship with coronary artery calcification. We like to explore the relationship between sleep quality and CAD/ISR.
Aims:This is a cross-sectional and follow-up study. We analysis the relationship of sleep quality on coronary artery disease(CAD) and in stent restenosis(ISR). Further, we explore the mechanism of relationship between the sleep quality and CAD/ ISR by examining the biomarkers in the pathway of sleep-CAD/ISR.
Methods: We include patients who were diagnosed as CAD by coronary arteriography. Sleep duration and quality were evaluated from sleep questionnaire. During the 6 months and 9-12months, we follow up the patients who got PCI and get information of Major Adverse Cardiovascular Events (MACE) from follow-up questionnaire. On 9-12 months after PCI, coronary arteriography were produced in PCI patients. Biomarkers were tested during the follow-up.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 30 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Clinical diagnosis of Coronary artery disease
- •PCI patients in the follow-up
- •written informed consent
Exclusion Criteria
- •Heart failure; renal failure; secondary hypertension;valvular heart disease ;Cancer;
Outcomes
Primary Outcomes
In-stent restenosis
Time Frame: 9-12 months from PCI
The rate of in stent restenosis
Secondary Outcomes
- MACE(6months, 12months)
Investigators
Hongjian Wang
Principal Investigator
China National Center for Cardiovascular Diseases