The Effects of Lifelong Endurance and Strength Training on the Central and Peripheral Cardiovascular Responses
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Heart Rate (HR)
研究概览
简要总结
Cardiovascular diseases represent the first mortality cause in the world. Ageing is considered as the most prominent risk factor for this kind of diseases. Also, hypertension represents one of the modifiable risk factors. Blood pressure response to exercise is governed by three systems: central command, baroreflex, and a feedback mechanism originating in the skeletal muscle. An abnormal cardiovascular response to exercise facilitates the occurrence of cardiovascular events. The goal of the study is to characterize the cardiovascular response in lifelong trained individuals and explore the potential benefits of endurance and strength training on cardiovascular regulation to exercise onset.
详细描述
Population ageing represents a problem both for health outcomes and for social dynamics in the social welfare states. Currently, the over 60 represents the fastest growing segment of the population. Despite a downward trend in the incidence of cardiovascular diseases, they remain the main culprits for what concern mortality rates in the world. Increasing age is considered the major risk factor for cardiovascular mortality.
One of the main components of the cardiovascular response to exercise is dictated by the exercise pressor reflex originating in the exercising muscle and responding to metabolic and mechanical stimuli. Research indicates that at least 20% of the regulation of blood pressure could be ascribed to these cardiovascular reflexes. A dysfunctional reflex-mediated response increases the chances of cardiovascular events that may end up in severe consequences.
Chronic exercise training is recognized to be an important tool to control blood pressure. The mechanisms through which exercise exerts its effect are multiple. Among these, an improvement of the neural control of the reflex originating in the muscle seems a likely contributor. However, at present, the effect of chronic exercise training on the EPR response in the elderly has not been elucidated. The aim of the study is to characterize the central and peripheral cardiovascular response in the lifelong endurance and strength trained elders population.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •History of cardiovascular events/diseases
- •Respiratory, musculoskeletal, renal, and insulin-resistant diseases
- •Hypercholesterolemia
- •Use of beta-blockers
结局指标
主要结局
Heart Rate (HR)
时间窗: 1 week after recruitment of the subject - We will measure the change from baseline to peak (peak response in HR due to PLM)
Difference in heart rate between groups to passive leg movement (PLM)
Muscle Sympathetic Nerve Activity - Microneurography
时间窗: 1 week after recruitment - We will measure the change from baseline to mean value (during stimulation)
Difference in muscle sympathetic nerve activity between groups to the different stimulations
Mean Arterial Blood Pressure (MAP)
时间窗: 1 week after recruitment of the subject - We will measure the changes from baseline to the steady state response ( average of 3rd minute)
Difference in MAP between groups to post-exercise cuff occlusion
次要结局
- Muscle oxidative capacity in vivo / blood pressure response(10 days after recruitment - Cross-sectional comparison at one time point only)
研究者
Massimo Venturelli, PhD
Assistant Professor
Universita di Verona