Palliation of Dyspnea With Morphine in Patients With Interstitial Lung Disease
Overview
- Phase
- Phase 4
- Intervention
- Morphine hydrochloride
- Conditions
- Interstitial Lung Disease
- Sponsor
- University of Aarhus
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- VAS dyspnea score
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
36 patients with interstitial lung disease will be randomized to 1 weeks treatment with morphine hydrochloride as oral linctus 5 mg, four times a day, and 5 mg as needed up to 4 times a day, or corresponding doses of placebo.
VAS score for dyspnea will be evaluated after 1 hour and 1 week at follow up. Other questionnaires will also be evaluated (GAD-7, K-BUILD, Leicester score)
Investigators
Charlotte Andersen
MD, PhD
University of Aarhus
Eligibility Criteria
Inclusion Criteria
- •A diagnosis of interstitial lung disease (IPF, NSIP, RA-ILS, Scl-ILS, MCTD-ILS, asbestous, drug induced ILD, unclassified ILD)
- •Dyspnea corresponding to Medial Research Councils (MRC) dyspnea score ≥ 3
- •Written consent
- •Age ≥ 18 years
- •Competent
- •For fertile women: Negative pregnancy test
- •For fertile and sexually active participants: Use of safe anti-conceptionals
Exclusion Criteria
- •Ongoing infection
- •Decreased lung function to a degree which makes any form of respiratory depression life threatening
- •Treatment with morphine or morphine analogues
- •Allergy towards morphine hydrochloride
Arms & Interventions
Morphine
18 patients treated with oral morphine hydrochloride linctus 5 mg 4 four times daily and as needed up to 4 times daily
Intervention: Morphine hydrochloride
Placebo
18 patients treated with oral linctus corresponding to 5 mg morphine hydrochloride, four times daily and as needed up to 4 times daily
Intervention: Placebo
Outcomes
Primary Outcomes
VAS dyspnea score
Time Frame: 1 week
Secondary Outcomes
- Oxygen saturation(1 hour and 1 week)
- K-bild questionnaire(1 week)
- GAD-7 questionnaire(1 week)
- 6 min walk test(1 hour and 1 week)
- Leicester Score(1 week)