Effects of Anesthetic Techniques on Renal Function

Completed

• Conditions: Acute Kidney Injury; Congenital Heart Disease
• Interventions: Other: Total intravenous anesthesia; Other: inhalation anesthesia

• Registration Number: NCT04030481
• Lead Sponsor: Huiying Shao

Brief Summary

This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.

Detailed Description

Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.

Study Timeline

• Study Start: 2019-01-01
• Study First Submitted: 2019-07-02
• Study First Submitted QC: 2019-07-21
• Study First Posted: 2019-07-24
• Primary Completion: 2019-09-30
• Study Completion: 2019-09-30
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-17
• Last Update Posted: 2019-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• children with congenital heart disease
• <3 years of age

Exclusion Criteria

• preoperative renal insufficiency;
• renal malformation, kidney absence

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group B: Propofol, sufentanil and rocuronium	Total intravenous anesthesia	propofol (4-12 mg/kg/h) and sufentanil (0.5-2 mcg/kg/h/) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required
Group A: Sevoflurane, sufentanil and rocuronium	inhalation anesthesia	sevoflurane (1-3%)and sufentanil (0.5-2 mcg/kg/h) and rocuronium (0.3～0.6mg/kg/h) used intraoperatively as required

Primary Outcome Measures

Name	Time	Method
renal blood flow	2 days	Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)

Secondary Outcome Measures

Name	Time	Method
creatinine	3 and 4 days	Changes of creatinine before and 3 days after acquisition, unit (mmol/L)
Mean arterial pressure	2 days	Mean arterial pressure synchronized with renal blood flow was recorded, unit (mmHg)
cardiopulmonary bypass (CPB) time	24 hours	Cardiopulmonary bypass time was recorded, unit(minutes)
neutrophil gelatinase-associated lipocalin , NGAL	2 days	Changes of blood NGAL were obtained before and 2 hours after surgery, unit(ng/ml)

Trial Locations

Locations (1)

Children's Hospital of Fudan University; 🇨🇳 Shanghai, Shanghai, China