Anesthesia and Acute Kidney Injury After Nephrectomy
- Registration Number
- NCT04474600
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.
- Detailed Description
Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 324
- Adults patients scheduled for elective open nephrectomy
- Patients diagnosed with acute kidney injury preoperatively
- Patients who have chronic kidney disease over stage 5 (estimated glomerular filtration rate [eGFR] <15 ml/kg/1.73m2) or have regular hemodialysis preoperatively
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Inhalation group Desflurane Patients receiving inhalation anesthesia using desflurane TIVA group Propofol Patients receiving the total intravenous anesthesia using propofol
- Primary Outcome Measures
Name Time Method the incidence of acute kidney injury during the postoperative seven days acute kidney injury (diagnosed by KDIGO criteria)
- Secondary Outcome Measures
Name Time Method estimated glomerular filtration rate postoperative day 1, 3, 14 postoperative result of estimated glomerular filtration rate
Length of hospital stay during the postoperative two weeks length of hospital stay
Length of intensive care unit stay during the postoperative two weeks length of intensive care unit stay
serum creatinine postoperative day 1, 3, 14 postoperative result of serum creatinine
the incidence of postoperative complications during the postoperative two weeks urine leakage, prolonged ileus, wound infection, retroperitoneal abscess, pneumonia, reoperation, etc.
biomarker of renal injury postoperative day 1, 3, 14 postoperative result of biomarker of renal injury
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of