To compare the efficacy of Opioid free analgesia with Magnesium sulphate and Ketamine versus opioid analgesia with Morphine in perioperative period for head and neck oncosurgeries by total intravenous anaesthesia technique.
Phase 4
Not yet recruiting
- Conditions
- Health Condition 1: C06- Malignant neoplasm of other and unspecified parts of mouth
- Registration Number
- CTRI/2022/12/048378
- Lead Sponsor
- Sreya Ramachandran
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA 1 OR 2 , undergoing elective head and neck oncosurgey.BMI between 18 to 35Kg/m2. who are ready to give written informed consent
Exclusion Criteria
Patient refusal , ASA 3 and 4 patients , pregnants ,lactating mothers ,deteriorating neurological disorders ,liver disease, renal disease ,cardiovascular disease with EF less than 40.known drug allergy.chronic pain on opioid or other analgesic .calcium channel blocker treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Perioperative analgesia. <br/ ><br>Timepoint: 0 hours to 48 hours of surgery. <br/ ><br>
- Secondary Outcome Measures
Name Time Method intraoperative haemodynamic stability.Timepoint: 24 hours
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie magnesium sulfate and ketamine's analgesic effects in opioid-free TIVA for head and neck oncosurgeries?
How does opioid-free analgesia with magnesium and ketamine compare to morphine-based analgesia in postoperative pain management for oral cavity malignancies?
Are there biomarkers predicting response to Sreya Ramachandran's CTRI/2022/12/048378 trial using magnesium-ketamine versus morphine in head and neck cancer surgeries?
What adverse event profiles differentiate magnesium-ketamine from morphine in Phase IV opioid-free TIVA for head and neck oncosurgeries?
How does the CTRI/2022/12/048378 magnesium-ketamine regimen compare to other non-opioid adjuvants like NSAIDs in multimodal analgesia for oral neoplasms?