Clonal hematopoiesis in young patients with ischemic stroke

• Conditions: I63; G45; Cerebral infarction; Transient cerebral ischaemic attacks and related syndromes

• Registration Number: DRKS00026954
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-10-22
• Study Completion: 2023-04-01
• Results First Posted: 2023-04-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 248

Inclusion Criteria

Ischemic stroke of undetermined origin after routine diagnostics before transesophageal echocardiography

Exclusion Criteria

determined stroke etiology

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of clonal hematopoiesis<br>Analysis of somatic mutations defining clonal hematopoiesis is carried out on a myeloid targeted gene panel using next generation sequencing. Patients’ DNA was isolated from peripheral leukocytes of venous blood. The test is performed after patients are recruited and blood samples are collected.

Secondary Outcome Measures

Name	Time	Method
Association of clonal hematopoiesis with clincial variables, atherosclerosis traits, and stroke etiology