Neuronal Effects of Exercise in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 140
- 试验地点
- 2
- 主要终点
- Resting-state neuronal response
研究概览
简要总结
This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of schizophrenia or schizoaffective disorder
- •Between 21 and 70 years of age
- •Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications
- •Weight stable within 5 percent for the last 6 months
排除标准
- •Pregnancy
- •Substance abuse
- •Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia)
- •MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)
结局指标
主要结局
Resting-state neuronal response
时间窗: 14 weeks
Neuronal response (default mode network) during rest
Neuronal response to visual food cues
时间窗: 14 weeks
Neuronal response (insula) while viewing visual food cues
次要结局
- Fasting leptin(14 weeks)
- Appetite Rating on a visual analogue scale (VAS)(14 weeks)
- Fasting ghrelin(14 weeks)