Comparison the effect of Metformin and Rosiglitazone, alone and in combination, to treat polycystic ovary syndrome.
Phase 2
- Conditions
- Polycystic ovarian syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT201605257513N12
- Lead Sponsor
- Vice chancelor of research of Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 44
Inclusion Criteria
females between 18-40 years old; euthyroid; non smoker; normal physical condition; not consumption of drugs that change sexual hormones metabolism for at least 1 month before trial; not using contraceptive pills for at least 3 months before the trial.
Exclusion criteria: classic 21_hydroxilase deficiency; hyperprolactinemia; androgen producing tumor; pregnancy; impaired liver tests or kidney function disorder; type 2 Diabetes; anemia; thrombocytopenia; explicit hypertension.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Ovarian size. Timepoint: At the beginning of the study, after one-drug usage period, after the period of treatment with combination of two drugs. Method of measurement: Trans vaginal sonography.;Endometrium density. Timepoint: At the beginning of the study, after one-drug usage period, after the period of treatment with combination of two drugs. Method of measurement: Trans vaginal sonography.
- Secondary Outcome Measures
Name Time Method Blood sugar. Timepoint: At the beginning of the study, after one-drug usage period, after the period of treatment with combination of two drugs. Method of measurement: Laboratory tests.;Hirsutism. Timepoint: At the beginning of the study, after one-drug usage period, after the period of treatment with combination of two drugs. Method of measurement: Ferriman criteria.;BMI. Timepoint: At the beginning of the study, after one-drug usage period, after the period of treatment with combination of two drugs. Method of measurement: Division of weight to squared hieght.