Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials

Not Applicable

Completed

• Conditions: TMJ Disc Disorder
• Interventions: Procedure: intra-articular injection with Hyaluronic Acid.; Procedure: intra-articular injection with Platelet lysate (PL).

• Registration Number: NCT06441279
• Lead Sponsor: Mansoura University

Brief Summary

comparing the clinical efficacy of intra-articular injection of platelet lysate (PL), versus Hyaluronic Acid after arthrocentesis in the management of patients with anterior disc displacement with reduction.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-01
• Study First Submitted: 2024-05-29
• Study First Submitted QC: 2024-05-29
• Study First Posted: 2024-06-04
• Primary Completion: 2024-10-01
• Study Completion: 2024-10-01
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-03
• Last Update Posted: 2024-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients that will be diagnosed with anterior disc displacement with reduction (ADDWR) both clinically and through magnetic resonance imaging scan (MRI).
• Patients who will not respond to a previous conservative therapy.
• Patients with pain in temporomandibular joints.
• Patients with normal or limitation in mouth opening.
• Patients with clicking sound.

Exclusion Criteria

• Patients with previous invasive TMJ surgical procedures.
• Patients with inflammatory or connective tissue diseases.
• Patients with neurologic disorders.
• Patients with history of bony or fibrous adhesion.
• Patients having gross mechanical restrictions and condylar fractures.
• Patients with psychological problems.
• Patients receiving anti-coagulation treatment, non-steroidal anti-inflammatory drugs within 48 hours pre-operatively, corticosteroid injection at the treatment site within one month or systemic use of corticosteroids within 2 weeks.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group 2	intra-articular injection with Hyaluronic Acid.	30 patients that will have intra-articular injection of Hyaluronic Acid.
group 1	intra-articular injection with Platelet lysate (PL).	30 patients that will have intra-articular injection of 2 ml of Platelet lysate (PL).

Primary Outcome Measures

Name	Time	Method
Maximum inter-incisal opening	6 months	Maximum inter-incisal opening will be measured by Vernier caliper and this will be recorded by photographs.

Trial Locations

Locations (1)

Heba Elsheikh; 🇪🇬 Mansoura, Egypt, Egypt