Transcranial Direct Current Stimulation in Autistic Spectrum Disorder
- Conditions
- Autistic Disorders Spectrum
- Interventions
- Device: DLPFC-R (F4) TDCSDevice: DLPFC-L (F3) and DLPFC-R (F4) TDCSDevice: sham-tDCS
- Registration Number
- NCT05311982
- Lead Sponsor
- Federal University of Paraíba
- Brief Summary
To understand the changes in the resting electroencephalogram (EEG) brain networks of children and adolescents with autistic spectrum disorder (ASD) induced by transcranial direct current stimulation (tDCS), we asked two questions. First: how can tDCS modulate the expression of neural network dynamics? Second: how can tDCS modulate functional connections at specific frequencies? We hypothesized that the tDCS mechanism results in increased cortical frequencies in the areas under the anode, which may reflect an increase in synaptic connectivity, and that this tDCS-related increase changes connection profiles at specific frequencies important for ASD, indicating improvement in symptoms. To verify this improvement, the researchers used the Autism Treatment Evaluation Checklist (ATEC) after an intervention, comparing baseline scores with post-treatment scores.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Patients with ASD reported by a Neuropediatrician; Age group between 5 and 18 years; Mild and moderate clinical symptoms
Patients with severe mental illness; Use of a pacemaker or other metal device on the body; Brain tumor or intracranial infection; Uncooperative parents or caregivers; Epilepsy; structural change in the skull
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description DLPFC-L F3 (Block A) sham-tDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in DLPFC-L F3 (Block A) tDCS combined in DLPFC-L (F3) and DLPFC-R (F4) DLPFC-L (F3) and DLPFC-R (F4) TDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in tDCS combined in DLPFC-L (F3) and DLPFC-R (F4) DLPFC-L F3 (Block A) DLPFC-R (F4) TDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in DLPFC-L F3 (Block A) tDCS combined in DLPFC-L (F3) and DLPFC-R (F4) DLPFC-R (F4) TDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in tDCS combined in DLPFC-L (F3) and DLPFC-R (F4) DLPFC-L F3 (Block A) DLPFC-L (F3) and DLPFC-R (F4) TDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in DLPFC-L F3 (Block A) tDCS combined in DLPFC-L (F3) and DLPFC-R (F4) sham-tDCS The study was developed through a triple-blind, crossover, randomized, placebo-controlled clinical trial (dummy tDCS). Participants were randomized into three groups receiving unilateral tDCS in tDCS combined in DLPFC-L (F3) and DLPFC-R (F4)
- Primary Outcome Measures
Name Time Method to compare the effectiveness of Neuromodulation techniques - transcranial direct current stimulation (tDCS) - in the treatment of people with Autism Spectrum Disorder 7 weeks EEG and TDCS
- Secondary Outcome Measures
Name Time Method Check the effects of tDCS modulations on cognitive responses through Autism Treatment Evaluation Checklist 7 weeks ATEC and EEG
Trial Locations
- Locations (2)
Suellen Marinho Andrade
🇧🇷João Pessoa, Paraíba, Brazil
Federal University of Paraíba,Department of Psychology
🇧🇷João Pessoa,, Paraiba, Brazil