Effects of Intraoperative Oxygen Therapy on Oxygenation and Reactive Oxygen Species Levels of Newborns Born Via Elective Cesarian Section
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obstetrical Complication of Anesthesia
- Sponsor
- Szeged University
- Enrollment
- 107
- Locations
- 1
- Primary Endpoint
- Hyperoxia Newborns
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
In this study the investigators examine the effects of intraoperative oxygen administration to the mother on certain enzyme functions of the newborn. With this object blood samples are taken from the newborn's umbilical chord - which is otherwise a routine practice at the investigators clinic - and the mother's radial artery in parallel with umbilical clamping and cutting for blood gas and reactive oxygen species analyses. Samples are analyzed locally in a properly equipped laboratory.
Detailed Description
Whole-blood superoxide and hydrogen peroxide production was measured from the newborn's umbilical chord.
Investigators
Domonkos Trásy
clinician
Szeged University
Eligibility Criteria
Inclusion Criteria
- •Elective cesarean section.
- •Signed informed consent form.
Exclusion Criteria
- •Subject meets the definition of a vulnerable subject as defined in International Organization for Standardization 14155:2011.
Outcomes
Primary Outcomes
Hyperoxia Newborns
Time Frame: through study completion up to two years
We measured umbilical vein blood gas parameters.
Secondary Outcomes
- Maternal hyperoxia(through study completion up to two years)
- Alterations in newborns' enzyme functions due to maternal hyperoxia(through study completion up to two years)