Effects of Intraoperative Oxygen Therapy on Oxygenation of Newborns Born Via Elective Cesarian Section
- Conditions
- Obstetrical Complication of Anesthesia
- Interventions
- Other: Oxygen
- Registration Number
- NCT02804555
- Lead Sponsor
- Szeged University
- Brief Summary
In this study the investigators examine the effects of intraoperative oxygen administration to the mother on certain enzyme functions of the newborn. With this object blood samples are taken from the newborn's umbilical chord - which is otherwise a routine practice at the investigators clinic - and the mother's radial artery in parallel with umbilical clamping and cutting for blood gas and reactive oxygen species analyses. Samples are analyzed locally in a properly equipped laboratory.
- Detailed Description
Whole-blood superoxide and hydrogen peroxide production was measured from the newborn's umbilical chord.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 107
- Elective cesarean section.
- Signed informed consent form.
- Subject meets the definition of a vulnerable subject as defined in International Organization for Standardization 14155:2011.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Oxygen support Oxygen 5 liter / minute oxygen has given to the mothers on face mask.
- Primary Outcome Measures
Name Time Method Hyperoxia Newborns through study completion up to two years We measured umbilical vein blood gas parameters.
- Secondary Outcome Measures
Name Time Method Maternal hyperoxia through study completion up to two years We measured arterial blood gas parameters of the mother from radial artery.
Alterations in newborns' enzyme functions due to maternal hyperoxia through study completion up to two years We measured umbilical vein reactive oxygen species (ROS) of the newborn.
Trial Locations
- Locations (1)
Department of Anaesthesiology and Intensive Therapy
🇭🇺Szeged, Csongrád, Hungary