Intraoperative Different Concentrations Oxygen And Oxidatıve Stress Markers

Not Applicable

Completed

• Conditions: Hyperoxia; Stress
• Interventions: Procedure: taking arterial blood sample through the injector

• Registration Number: NCT05099523
• Lead Sponsor: Zonguldak Bulent Ecevit University

Brief Summary

The aim of the study was to assess the effect of intraoperative oxygen (O2), which was applied at 30% and 50% concentrations on patients who had undergone septoplasty surgery, on Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Oxidative Stress Index (OSI).

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-01
• Primary Completion: 2021-05-30
• Study Completion: 2021-05-30
• Study First Submitted: 2021-09-08
• Status Verified: 2021-10
• Study First Submitted QC: 2021-10-18
• Last Update Submitted: 2021-10-18
• Study First Posted: 2021-10-29
• Last Update Posted: 2021-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients aged between 18-60 years,
• ASA I-II risk class with a minimum operative time of 1.5 hour(s) for whom septoplasty operation under elective conditions

Exclusion Criteria

• metabolic, endocrine, hepatic, cardiac, or renal diseases,
• malignancies and who used a drug with antioxidant properties such as vitamin E-C
• acetylcysteine in the last 48 hours,
• patients requiring intraoperative 100% O2 inhalation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group II	taking arterial blood sample through the injector	30%Fio2
group I	taking arterial blood sample through the injector	50%Fio2

Primary Outcome Measures

Name	Time	Method
EFFECTS OF INTRAOPERATIVE OXYGEN USED AT DIFFERENT CONCENTRATIONS ON OXIDATIVE STRESS MARKERS	end of the surgery	TAS and TOS values occurring at different oxygen concentrations

Trial Locations

Locations (1)

Zonguldak Bülent Ecevit University; 🇹🇷 Zonguldak, Kozlu, Turkey