A Prospective, Observational Trial on the Diagnostic and Prognostic of LM
- Conditions
- Lung NeoplasmsMeningeal Carcinomatosis
- Registration Number
- NCT02607605
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
The primary purpose of this study is to compare the positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid in Advanced lung cancer with leptomeningeal metastases.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Patient who was confirmed primary lung cancer by pathologic histology or cytology
- Adult patients (≥18 years and ≤75 years). ECOG Performance Status 0 or 1.Life expectancy of at least 12 weeks.
- Clinical symptoms and imaging tests are highly suspicious of advanced lung cancer with leptomeningeal metastases
- Without contraindications to lumbar puncture
Exclusion Criteria
- Patients who have primary benign or malignant brain tumor and metastatic malignant brain tumor
- Patients who have contraindications to lumbar puncture
- Serious uncontrolled systemic disease including active infection,uncontrolled hypertension,diabetes,unstable angina,congestive heart failure,myocardial infarction,severe arrhythmia which needs drugs,hepatic、renal and metabolic disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid 2 years
- Secondary Outcome Measures
Name Time Method The relationship between the number of cell-free DNA and OS 2 years
Trial Locations
- Locations (1)
Sun Yat-sen University of cancer center
🇨🇳Guangzhou, Guangdong, China