NCT02607605Unknown不适用
A Prospective, Observational Trial on the Diagnostic and Prognostic Value of Cell-free DNA in Advanced Lung Cancer With Leptomeningeal Metastases
Sun Yat-sen University1 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2015年8月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid
研究概览
简要总结
The primary purpose of this study is to compare the positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid in Advanced lung cancer with leptomeningeal metastases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient who was confirmed primary lung cancer by pathologic histology or cytology
- •Adult patients (≥18 years and ≤75 years). ECOG Performance Status 0 or 1.Life expectancy of at least 12 weeks.
- •Clinical symptoms and imaging tests are highly suspicious of advanced lung cancer with leptomeningeal metastases
- •Without contraindications to lumbar puncture
排除标准
- •Patients who have primary benign or malignant brain tumor and metastatic malignant brain tumor
- •Patients who have contraindications to lumbar puncture
- •Serious uncontrolled systemic disease including active infection,uncontrolled hypertension,diabetes,unstable angina,congestive heart failure,myocardial infarction,severe arrhythmia which needs drugs,hepatic、renal and metabolic disease
结局指标
主要结局
positive rate between the cell-free DNA and cytological examination of cerebrospinal fluid
时间窗: 2 years
次要结局
- The relationship between the number of cell-free DNA and OS(2 years)
研究者
Li-kun Chen
associate professor
Sun Yat-sen University
研究点 (1)
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