Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During Liver Transplantation

Completed

• Conditions: Effect of Bacterial Translocation
• Interventions: Diagnostic Test: PCR for bacterial translocation

• Registration Number: NCT03230214
• Lead Sponsor: Alexandria University

Brief Summary

The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-07-20
• Study First Submitted QC: 2017-07-25
• Study First Posted: 2017-07-26
• Study Start: 2017-08-03
• Primary Completion: 2017-10-24
• Study Completion: 2017-11-14
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-13
• Last Update Posted: 2018-01-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients with liver failure undergoing liver transplantation

Exclusion Criteria

• Age less than 18 years;
• Active overt infection;
• Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders...etc);
• Patients undergoing re-transplantation.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
DNA positive patients	PCR for bacterial translocation	patients who have bacterial DNA in their samples
DNA negative patients	PCR for bacterial translocation	patients who do not have bacterial DNA in their samples

Primary Outcome Measures

Name	Time	Method
antifactor X activity	at the beginning of surgery
change in the mean arterial blood pressure	at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
change in the cardiac output	at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
change in the heart rate	at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase

Trial Locations

Locations (1)

Elmoasah Hospital; 🇪🇬 Alexandria, Egypt