Effect of Bacterial Translocation on Haemodynamic and Coagulation Parameters During a Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- antifactor X activity
研究概览
简要总结
The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with liver failure undergoing liver transplantation
排除标准
- •Age less than 18 years;
- •Active overt infection;
- •Patients on oral or systemic anticoagulation or with known coagulopathic disorders apart from those caused by liver failure (eg.: Protein C or S deficiency, congenital platelet disorders and congenital coagulation disorders...etc);
- •Patients undergoing re-transplantation.
结局指标
主要结局
antifactor X activity
时间窗: at the beginning of surgery
change in the mean arterial blood pressure
时间窗: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
change in the cardiac output
时间窗: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
change in the heart rate
时间窗: at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase
次要结局
未报告次要终点
研究者
Heba Moharem
assisstant lecturer
Alexandria University