Tacrolimus in adult onset minimal change disease
Not Applicable
Completed
- Conditions
- Health Condition 1: null- Adult onset nephrotic syndrome.
- Registration Number
- CTRI/2017/12/010965
- Lead Sponsor
- IPGMER and SSKM Hospital kolkata
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
All patients aged over 18 years with biopsy-proven MCD with an Immunofluorescence staining negative for all stains and presence of nephrotic range proteinuria ( >3.5gms/24hours) will be taken for study.
Exclusion Criteria
The patients with any other glomerular or tubulo-interstitial pathology in the biopsy (including any overlap syndrome or variants of MCD), chronicity features on histopathology (interstitial fibrosis and tubular atrophy >20%), presence of active infection and prior exposure to any immunosuppressive agents for the same disease were excluded from the study. Patients with systemic diseases like SLE, diagnosed lymphoma/leukemia or suspicion of drug induced MCD were excluded.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Complete remission, partial remission in each groups, tacrolimus and steroid resistance measured at 12 and 18 months in steroid and tacrolimus groups.Timepoint: 6 months 12 months, 18 months
- Secondary Outcome Measures
Name Time Method Relapses, sustained remission, complications of therapy, drug dependency measured at 18 months.Timepoint: 6 months, 12 months, 18 months