The Features of Clinical Imaging, Disease Severity and Pregnancy Outcomes in Posterior Reversible Encephalopathy Syndrome With Preeclampsia or Eclampsia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 354
- 试验地点
- 1
- 主要终点
- biochemical parameters
研究概览
简要总结
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
详细描述
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients were diagnosed of PRES with PE or E
- •all patients provided written informed consent
排除标准
- •patients combined with other neurological disorders
- •patients combined with mental illness
结局指标
主要结局
biochemical parameters
时间窗: Biochemical indicators were collected within 1 week of the hospital stay.
The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L).
features of clinical imaging
时间窗: Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits.
The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved.
blood pressure(BP)
时间窗: The BP of patients was obtained immediately at the onset of symptoms.
hypertension：≥140/90mmHg
pregnancy outcomes
时间窗: From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year.
The PRES patients may have longer time of hospitalization.
次要结局
未报告次要终点
研究者
Dunjin Chen
Director of obstetrics
Guangzhou Medical University