The Features of Clinical Imaging, Disease Severity and Pregnancy Outcomes in Posterior Reversible Encephalopathy Syndrome With Preeclampsia or Eclampsia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Posterior Reversible Encephalopathy Syndrome
- Sponsor
- Dunjin Chen
- Enrollment
- 354
- Locations
- 1
- Primary Endpoint
- biochemical parameters
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.
Detailed Description
The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .
Investigators
Dunjin Chen
Director of obstetrics
Guangzhou Medical University
Eligibility Criteria
Inclusion Criteria
- •patients were diagnosed of PRES with PE or E
- •all patients provided written informed consent
Exclusion Criteria
- •patients combined with other neurological disorders
- •patients combined with mental illness
Outcomes
Primary Outcomes
biochemical parameters
Time Frame: Biochemical indicators were collected within 1 week of the hospital stay.
The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L).
features of clinical imaging
Time Frame: Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits.
The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved.
blood pressure(BP)
Time Frame: The BP of patients was obtained immediately at the onset of symptoms.
hypertension：≥140/90mmHg
pregnancy outcomes
Time Frame: From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year.
The PRES patients may have longer time of hospitalization.