Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease

Fondation Ophtalmologique Adolphe de Rothschild1 site in 1 country45 target enrollmentDecember 2014

ConditionsHorton Disease

Overview

Phase: N/A
Intervention: Not specified
Conditions: Horton Disease
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Enrollment: 45
Locations: 1
Primary Endpoint: MRI angiography mural inflammation
Status: Terminated
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The study aims at measuring the sensitivity and specificity of a series of imaging signs (recorded by magnetic resonance angiography, vascular tomodensitometry, vascular ultrasonography, retina angiography and retina optic coherence tomography) for the diagnosis of Horton disease, the gold standard being the result of temporal artery biopsy.

Registry

clinicaltrials.gov

Start Date

December 2014

End Date

June 2018

Last Updated

7 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2 major criteria and at least one minor criteria.
•Major criteria : Age \> 50 ans ; headache ; intermittent jaw or tongue pain ; visual impairment ; ESR \> 50 mm at 1h and/or CRP \> 8mg/l.
•Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever \>38°C, weight loss \>10%, anorexia, fatigue.

Exclusion Criteria

•Autoimmune disease
•Active infectious condition
•Malignant disease
•Condition counterindicating one or several of the protocol's imaging procedures : allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic foreign body...