Circadian disruption after anaesthesia and surgery in patients undergoing cardiac surgery.

Not Applicable

Completed

• Conditions: Circadian disruption following cardiac surgery; Other - Research that is not of generic health relevance and not applicable to specific health categories listed above; Sleep disruption following cardiac surgery

• Registration Number: ACTRN12608000640303
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-12-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All patients presenting for elective bypass cardiac surgery

Exclusion Criteria

Refusal, non-bypass surgery, patient requiring Magnetic Resonance Imaging at any stage during treatment, congenital heart disease

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sleep/ wake cycle disruption, the extent of which is measured using actigraphy and sleep diaries.[Three sets of measurements are taken - five to seven days pre-operatively, five to seven days immediately post-operatively and five to seven days immediately post-discharge. One sleep diary of one week is completed at each stage.];Circadian disruption, measured using vitalsense core body temperature monitoring equipment and salivary melatonin. Changes in melatonin levels and core body temperature show the extent, if any, of circadian disruption.[The three to four days of pre-operative core body temperature data, three to four days of post-operative data and three to four days of post-discharge data are collected. Salivary melatonin is also collected at nine half-hour intervals once at every stage. The pre-operative results are then compared to the post-operative to establish melatonin onset time and changes in core body temperature levels - these measurements are compared one week post-discharge.]

Secondary Outcome Measures

Name	Time	Method
Mood disturbance, measured using profile of mood states questionnaires[The profile of mood states questionnaire is taken one week pre-operatively, one week post-operatively and one week post-discharge. The results of the questionnaires are compared one week post-discharge.]