Comparative study of the intraoral and carotid plaque microbiome in patients with carotid stenosis: Analysis of the metagenome and metatranscriptome

Recruiting

• Conditions: I63.2; I65.2; K05.1; K05.2; K05.3; K05.4; K05.0; Periodontosis; Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries; Occlusion and stenosis of carotid artery

• Registration Number: DRKS00021598
• Lead Sponsor: Deutsche Gesellschaft für Parodontologie e. V.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Inpatients with obstrucive arterial disease and planned endarterectomy of the carotid artery
- Age: = 35 years
- At least 4 natural teeth
- German Caucasian origin
- no relationship between the study participants

Exclusion Criteria

- subgingival PA therapy within 6 months prior to sample collection
- systemic antibiotic therapy within 3 months before sample collection
- Pregnancy/nursing period

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterization of the intraoral microbial metagenome and metatranscriptome in patients with arterial obstructive disease of the carotid artery as a function of the pardontal status<br>

Secondary Outcome Measures

Name	Time	Method
Comparative study of the microbial metagenome and metatranscriptome intraorally and in cell material of the carotid artery.