ISRCTN14684459暂停未知
Comparing the mechanistic role of the carotid bodies in human heart failure with and without preserved ejection heart failure
niversity of Bristol0 个研究点目标入组 55 人开始时间: 2019年5月2日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 暂停
- 发起方
- 入组人数
- 55
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •All participants:
- •1. Aged 18-90 years
- •HFrEF participants:
- •As per the European Society of Cardiology (ESC) guidelines:
- •1. Signs and symptoms of heart failure AND
- •2. Raised natriuretic peptides AND
- •3. Evidence of reduced ejection fraction (EF < 40%)
- •HFpEF participants:
- •As per the European Society of Cardiology (ESC) guidelines:
- •1. Signs and symptoms of heart failure AND
- •2. Raised natriuretic peptides (e.g. NTproBNP) AND
- •3. Evidence of preserved ejection fraction (EF > 50%) AND
- •4. Objective evidence of cardiac functional and structural alterations
排除标准
- •All participants:
- •1. Requirement for oxygen therapy to maintain oxygen saturation
- •2. Oxygen saturations at rest < 92%
- •3. Chronic obstructive pulmonary disease (COPD) and known structural lung disease
- •4. Current smoker (within the last 2 months)
- •5. Acute coronary syndrome, coronary revascularisation or unstable angina in last 6 months
- •6. HF related hospitalisation in the last 1 month.
- •7. Transient ischaemic attack or stroke in the last 6 months
- •8. Surgery under general anaesthesia in the last 3 months
- •9. Change in regular medications within the last 1 month
- •10. Clinically significant neurological disorder, including peripheral neuropathy
- •11. Type 1 Diabetes Mellitus
- •12. Heart transplant
- •13. Haemodialysis or peritoneal dialysis
- •14. Pregnancy, breast feeding or recent unprotected intercourse
- •15. Palliative care/chemotherapy
- •16. Recreational drug use and/or intravenous drug use
- •17. Alcohol intake > 28 units/week
- •18. Febrile illness/clinically significant infection within two weeks of participation
- •19. Contraindications to dopamine administration:
- •19.1. Known phaeochromocytoma
- •19.2. Known hyperthyroidism
- •19.3. Known uncontrolled atrial or ventricular tachyarrhythmias
- •19.4. Known hypersensitivity to dopamine or any of the excipients
- •19.5. Participants on the following medications:
- •19.5.1. Monoamine oxidase I inhibitors
- •19.5.2. Phenytoin
- •19.5.3. Ergot alkaloids
- •19.5.4. Tricyclic antidepressants
- •19.5.5. Guanethidine
- •Healthy controls:
- •1. No history of hypertension
研究者
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