In vitro investigation into the potential regulating role of sphingolipids in lymphocyte proliferation.

Completed

• Conditions: not applicable; 10047954; 10003816

• Registration Number: NL-OMON40165
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

In order to be eligible to participate in this study, a subject must be at the age between 18 and 65 years old.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study: clinically relevant infection or inflammation, malignancy, any systemic disease, pregnancy.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the in vitro proliferation rate of lymphocytes,<br /><br>measured as the number of cells, after 72 hours of incubation with specific<br /><br>agonists or antagonists for the sphingosine-receptors and substrates or<br /><br>blockers of the sphingosine-kinase and -transporter (i.e. the ABC<br /><br>C1-transporter).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>