Effects of Narrowband UVB Phototherapy on Melanocyte Proliferation in Patients With Vitiligo
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Number of melanocytes per unit length of skin surface
研究概览
简要总结
The study offers narrowband UVB light therapy to patients who have 5% of their body involved with vitiligo.
The hypothesis is that Narrowband UVB promotes melanocyte proliferation in vitiligo lesions.
详细描述
All patients will receive phototherapy, with narrowband UVB, three times a week for six months, or a total of 78 treatments. 6mm punch skin biopsies (2) will be done prior to starting therapy, once during treatment (2) and at the completion of the study (2). Clinical assessments and photography will be done parallel to the skin biopsies. Results (clinically and histologically) will be analyzed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years of age or greater
- •Vitiligo with extensive skin involvement (>5% body surface affected).
排除标准
- •No treatment with topical steroids, calcineurin inhibitors or vitamin D analogs for at least 4 weeks prior to entering the study.
- •No treatment with systemic therapies, including methotrexate, etretinate, PUVA, or cyclosporine 4 weeks prior to entering the study.
结局指标
主要结局
Number of melanocytes per unit length of skin surface
时间窗: pre-treatment, early repigmentation, 75% repigmentation of total body
次要结局
- Clinical improvement(first visit and last visit)
研究者
Mary Sullivan-Whalen
Co-Investigator
Rockefeller University