Bone Fragility Evaluation by Dual X-Ray Absorptiometry (DXA) and CT-scan (vertebral Fracture and Scanographic Bone Attenuation Coefficient of the First Lumbar Vertebra SBAC-L1) in Obese Patients

Central Hospital, Nancy, France1 site in 1 country1,500 target enrollmentFebruary 23, 2020

ConditionsObesity Bariatric Surgery Candidate

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Obesity
Sponsor: Central Hospital, Nancy, France
Enrollment: 1500
Locations: 1
Primary Endpoint: scanographic bone attenuation coefficient of the first lumbar vertebra SBAC-L1
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This research will study the bone fragility in obese patients, on DXA and CT-scan, in a transversal study. The investigators want also to study the specific risk factors of bone fragility in these obese patients (relationship between body composition on whole body on DXA, fat mass and its location, lean mass, weight loss after surgery and SBAC-L1), to improve the bone screening.

Registry

clinicaltrials.gov

Start Date

February 23, 2020

End Date

August 23, 2021

Last Updated

last year

Study Type

Observational

Sex

All

Investigators

Sponsor

Central Hospital, Nancy, France

Responsible Party

Principal Investigator

Marine FAUNY

MD; Principal Investigator

Central Hospital, Nancy, France

Eligibility Criteria

Inclusion Criteria

•patients followed at Nancy university hospital for a bariatric surgery
•CT-scan and DXA performed before surgery, with maximum 1 year before the 2 exams

Exclusion Criteria

•\< 18 years
•Protected adults

Outcomes

Primary Outcomes

scanographic bone attenuation coefficient of the first lumbar vertebra SBAC-L1

Time Frame: November 2019-September 2020

on axial section of the first lumbar vertebra, with a region of interest

Secondary Outcomes

DXA: Bone mineral density BMD (spine, hip , femoral neck, wrist)(November 2019-September 2020)
DXA: T-score(November 2019-September 2020)
Vertebral fracture(November 2019-September 2020)
DXA: lean and fat mass(November 2019-September 2020)