Evaluation of Dual Energy X-ray Absorptiometry Scanners in the Identification of Atypical Femur Fractures - A Validation Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atypical Femur Fracture
- Sponsor
- University Health Network, Toronto
- Enrollment
- 285
- Locations
- 1
- Primary Endpoint
- HD-IVA visualization of incomplete femur fractures
- Status
- Active, not recruiting
- Last Updated
- 8 months ago
Overview
Brief Summary
DXA scanners are routinely used to assess bone mineral density (BMD) and fracture risk in osteoporosis patients. They provide detailed bone imaging in a low radiation setting. Hologic manufactures scanners that are able to perform high definition instant vertebral fracture assessment (HD-IVA) used to screen at-risk patients for asymptomatic spine fractures instantly and reliably at the same time they are having their yearly BMD. We wish to investigate whether this same proven technology (HD-IVA scan mode) used on femurs (the scan mode is now called SE Femur scans) can be used to screen for atypical fractures of the femur in patients at risk for these debilitating fractures. In this proof of concept study, we propose to examine whether DXA scanners can provide a sensitive low radiation screening method to identify incomplete AFFs in patients with known incomplete AFFs and in patients at risk.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Known AFF group
- •A subject must have experienced an incomplete atypical low trauma fracture of the femoral shaft;
- •Is a patient at the UHN osteoporosis clinic.
- •Comparison Group
- •Must be scheduled for a bone mineral density scan at UHN
- •Have been on any bisphosphonate for 5 years or longer, and;
- •Have unexplained symptoms of leg, hip, thigh, or knee pain.
Exclusion Criteria
- •There are no exclusions
Outcomes
Primary Outcomes
HD-IVA visualization of incomplete femur fractures
Time Frame: 1 day (one time point )
Hologic DXA scanner using the high-definition IVA (HD-IVA) mode on femur bones will be able to visualize incomplete femur fractures at least 90% of the time in patients with known incomplete AFF.