Effect of co-administration of quercetin on the endothelial dysfunction after continuous treatment of nitroglycerin in Japanese volunteers with aldehyde dehydrogenase2 *2 polymorphism: randomized crossover trial
- Conditions
- angina pectoris
- Registration Number
- JPRN-UMIN000033639
- Lead Sponsor
- SOUSEIKAI Fukuoka Mirai Hospital, Clinical Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 24
Not provided
1.History of cardiovascular disease 2.Severe hepatic or renal dysfunction 3.Volunteers who received other clinical study drug within 30 days 4.Woman who is pregnant or possibly be pregnant 5.History of severe allergy or allergic reaction to the drugs which are used in the present study 6.History of heart disease, glaucoma, peptic ulcer and aspirin-induced asthma 7.volunteers who have smoking habit 3 months before the start of this study 8.On medical treatment (exclude NSAIDs and sleeping pills taken as needed) 9.On medical treatment of phosphodiesterase 5 or agents with guanylate cyclase stimulating effect 10.systolic blood pressure<90 mmHg 11.Body weight <40 kg or >90 kg 12.Not appropriate to this study by other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relation between ALDH2 polymorphisms and the values of flow-mediated dilation, and oxidative stress (malondialdehyde).
- Secondary Outcome Measures
Name Time Method Relation between ALDH2 polymorphisms and blood pressure, pulse rate. Relation between ALDH2 polymorphisms and the rate of adverse events.