Quercetin on thalassemia induced depressio
- Conditions
- beta thalassemia major.Cooley anaemia Severe beta thalassaemia Thalassaemia: intermedia major
- Registration Number
- IRCT20091114002709N46
- Lead Sponsor
- Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 84
18 to 40 year old male and female beta thalassemia major patients
Inclination to cooperate and signing the written informed consent
A minimum of 2 years of blood transfusion history
blood specimen collection 20 days after the last blood transfusion
Regular and peculiar iron-chelating therapy with desferrioxamine
Vitamin C supplement intake with desferrioxamine
Uncontrollable and life threatening complication due to due to the supplement intake;; ; ; ; ; ;
A change in type or amount of the iron chelator
Pregnancy or lactation
Hepatitis infection and other metabolic or infectious diseases
Less than 80% compliance of supplement intake
Consumption of drugs that interfere with quercetin
Drinking more than 500 mg/day of beverages rich in flavonoids
Smoking or alcohol consumption
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Depression. Timepoint: before and after the intervention. Method of measurement: Beck's questionnaire.
- Secondary Outcome Measures
Name Time Method High-sensitivity C-reactive protein(hs-CRP). Timepoint: before and after the intervention. Method of measurement: using ELISA kit in Microgram/milliliter(micg/ml).;Tumor necrosis factor a(TNF-a). Timepoint: before and after the intervention. Method of measurement: using ELISA kit in Picrogram/milliliter(pg/ml).