Fiber-rich Foods, Weight Status, and the Gut Microbiota: A Comparative Study in NH Hispanic Adults at Risk for Food Insecurity

University of New Hampshire1 个研究点分布在 1 个国家目标入组 61 人开始时间: 2022年3月28日最近更新: 2025年3月28日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of New Hampshire
入组人数: 61
试验地点: 1
主要终点: LPS

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study will include a group of 60 Hispanic adults living in New Hampshire with or without overweight/obesity. The study aims to assess food access and intake of fiber-rich foods, characterize fecal microbiota composition, and assess the relationship between the intake of fiber-rich foods and components of the gut microbiota-gut-brain axis. These aims will be accomplished through biospecimen collection including a pre-collected stool sample, a fasting blood sample, and a Mixed Meal Tolerance Test (MMTT). In addition, participants will answer questionnaires on dietary intake, food insecurity and access, physical activity, eating behavior, and sociodemographic characteristics.

详细描述

This study will include Hispanic adults living in New Hampshire with or without overweight/obesity. In a group of 60 participants, the study aims to assess food access and intake of fiber-rich foods, characterize fecal microbiota composition, and assess the relationship between the intake of fiber-rich foods and components of the gut microbiota-gut-brain axis.

The study involves biospecimen collection including a pre-collected stool sample, a fasting blood sample, and a Mixed Meal Tolerance Test (MMTT). In addition, participants will answer questionnaires on dietary intake, food insecurity and access, physical activity, eating behavior, and sociodemographic characteristics.

Pre-collected stool samples will be obtained from participants. Anthropometric measurements will be collected at the time of the study visit including height, weight, and waist and hip circumference. BMI will be calculated. An intra-venous catheter will be inserted by a healthcare professional to first collect a fasting blood sample, and will remain inserted for all following blood samples. Subjects will then undergo a Mixed Meal Tolerance Test (MMTT), a validated metabolic assessment in which the participant ingests a liquid mixed meal (e.g., Boost or Ensure), and blood samples are subsequently collected 15min, 30min, 60min and 120min after meal ingestion.

In the intervals between blood sample collections, subjects will complete questionnaires on dietary intake, food insecurity and access, physical activity, eating behavior, and sociodemographic characteristics. The following validated measures will be used to assess these aims:

USDA Household Food Sufficiency Questionnaire
Perceived Nutrition Environment Measurements Survey (NEMS-P)
Shortened version of the Three Factor Eating Questionnaire
Latino Dietary Behaviors Questionnaire (LDBQ)
Global Physical Activity Questionnaire
Short Acculturation Scale for Hispanics
NHANES Weight History Questionnaire
Medical History Questionnaire

研究设计

研究类型: Observational
观察模型: Other
时间视角: Cross Sectional

入排标准

年龄范围: 18 Years 至 55 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Two groups of participants will be recruited:
•Healthy BMI (20-25 kg/m2, n=30), and
•Overweight/Obese BMI (>28 kg/m2, n=30)
•Other inclusion criteria are as follows:
•Adult men and women (18-55 years of age) residing in a SNAP-eligible households;
•Self-identifying as Hispanic or Latino, and with origin or cultural background from a Spanish-speaking Latin American country;
•Willingness and ability to provide a signed informed consent; and
•Willingness to complete study visits and participate in all aspects of the study.

排除标准

•Adults reporting any of the following conditions will be excluded from the study:
•Diagnosed type 2 diabetes, chronic kidney or liver disease, cancer, chronic gastrointestinal conditions, cognitive impairment or incapacitating mental health problems, lack of mobility and physical independence, self-reported weight loss >5 kg within past 6 months, history of communicable or chronic diseases, medication use or surgery that would preclude safe and active study participation, bariatric surgery, antibiotic use within past 3 months, ongoing participation in other clinical trials, use of anti-obesity medications within the past year, inability to communicate in oral and written form in English and/or Spanish, and habitual consumption of more than two alcoholic drinks per day or of illegal drugs.