Conventional Mechanical Ventilation and High Frequency Percussive Ventilation: Comparison of Their Effects on Alveolar Recruitment and Distension by CT-scan in Early ARDS Patients
Not Applicable
- Conditions
- ARDS
- Interventions
- Device: High frequency percussive ventilation
- Registration Number
- NCT02885584
- Lead Sponsor
- Assistance Publique Hopitaux De Marseille
- Brief Summary
High frequency percussive ventilation (HFPV) is a high frequency ventilation mode in which high frequency pulses accumulate to generate a low frequency tidal volume at a controlled airway pressure. Previous studies have suggested a protective effect of HFPV on lung injury. The goal of our study is to compare, in early ARDS patients, the effects of conventional mechanical ventilation and of high frequency percussive ventilation on alveolar recruitment and distension evaluated by CT-scan
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Patient undergoing invasive ventilation for more than 24h
- ARDS patient
Exclusion Criteria
- Pneumothorax drained or not
- Patient undergoing extracorporel mechanical oxygenation
- Patient who had a pneumonectomy partiel or total
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Transpulmonary pressure controlled mechanical ventilation High frequency percussive ventilation transpulmonary pressure will be used for ventilation settings
- Primary Outcome Measures
Name Time Method Percent of patients exhibiting under HFPV an increase of at least 15% of normally aerated end-expiratory lung volume 4 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assistance Publique-Hôpitaux de Marseille
🇫🇷Marseille, France