Prospective, epidemiological, clinical and laboratory programme to plan and evaluate strategies to control enteric fever in different settings in Africa and Asia

niversity of Oxford0 sites423,618 target enrollmentOctober 20, 2016

Overview

Registry

who.int

Start Date

October 20, 2016

End Date

December 31, 2020

Last Updated

4 years ago

Study Type

Observational

Sex

All

Sponsor

•Census study, WASH and HUS survey:
•Census participants will be the population (n \=100,000, all ages) residing in a demarcated geographic area that is a known catchment population for each of the 3 typhoid surveillance sites. Participants will be recruited and consented as households.
•1\. Head of household / key informant is willing and competent to give informed consent for participation of the household in the study
•2\. Head of household / key informant is Male or Female, aged 18 years or above
•3\. Household is within the census area
•Passive surveillance:
•This component will include all patients presenting at any of the clinical surveillance sites in each country with a history of subjective fever \>72 hours with or without objective fever on presentation.
•1\. Individual willing and competent to give informed consent if \=18 years or the parent/legal guardian if participant \<18 years;
•2\. Able to comply with study requirements
•3\. In addition those considered index cases (for the household contact component) must be resident in a household enrolled in the census survey

•Census study, WASH and HUS survey:
•1\. Head of household/key informant not willing for household to participate
•2\. Unable to identify Head of household/key informant
•Passive surveillance:
•1\. Previous enrolment into this component (e.g. from previous attendance at healthcare facility with persistent fever)
•2\. Other underlying disease which can be rapidly diagnosed such as Malaria in children (Blantyre)
•Household contacts (index cases):
•1\. Not a resident of household of index case at time of his/her primary illness
•2\. Fever at presentation in index case confirmed not due to S. Typhi or Paratyphi fever
•3\. Deemed clinically unsuitable by the survey team (e.g. terminally ill)