Effect of Folic Acid Treatment in Coronary Artery Disease
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT00300352
- Lead Sponsor
- University of Oxford
- Brief Summary
We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function
- Detailed Description
Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 60
Clinical diagnosis of coronary artery disease
Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Improvement in noninvasive measures of vascular function
- Secondary Outcome Measures
Name Time Method Improvement in laboratory measures of vascular function
Trial Locations
- Locations (1)
University of Oxford
🇬🇧Oxford, United Kingdom