NCT00300352Unknown2 期
Effect of Folic Acid Treatment in Coronary Artery Disease
适应症
相关药物
试验速览
- 阶段
- 2 期
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Improvement in noninvasive measures of vascular function
研究概览
简要总结
We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function
详细描述
Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of coronary artery disease
排除标准
- •Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants
结局指标
主要结局
Improvement in noninvasive measures of vascular function
次要结局
- Improvement in laboratory measures of vascular function
研究者
研究点 (2)
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