Assessment of Bioavailability of Krill Oil Compared to Fish Oil in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Bioavailability
研究概览
简要总结
The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo.
详细描述
The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo. An additional purpose is to evaluate the lipid-lowering efficacy and safety of consumption of Krill Oil and Fish Oil to a placebo product. It has been shown that the ingestion of Krill Oil leads to better absorption of omega-3 fatty acids compared to ingestion of Fish Oil. It was also shown that consumption of krill oil and fish oil result in a favorable modification of lipid profiles. Therefore, it is anticipated that consumption of these krill oil and fish oil will improve lipid profile, as well as other health-related markers and will be safe and well tolerated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy men and premenopausal not pregnant or nursing women between 18 and 49 years old.
排除标准
- •rheumatoid arthritis
- •chronic illness
- •cardiovascular problems
- •dyslipidemia
- •liver and kidney disease
- •endocrine or metabolic disease
- •inflammatory bowel disease
- •pancreatitis
- •gallbladder or biliary disease
- •neurological/psychological disease
- •bleeding disorders
- •experienced platelet abnormalities
- •gastrointestinal disorders that could interfere with fat absorption
- •hypertension
- •history of cancer
- •an intention to lose weight
- •use of anticoagulant
- •serum triglycerides (TG) >200 mg/dL, and/or total cholesterol (TC) >240 mg/dL, and/or LDL-cholesterol (LDL-C) >160 mg/dL
- •hypertension or lipid lowering medications
- •consumption of more than one alcoholic drinks/day
- •Consumption of more than one fish or seafood serving
- •one month prior to the start of the study
- •omega-6 fatty acids in the past 6 months
- •planned to consume seafood products or fish or to use any omega-3 or omega-6 fatty acids nutritional supplements at anytime in the duration of the study
- •planned to to become pregnant during the study period
- •allergies to fish seafood or corn
结局指标
主要结局
Bioavailability
时间窗: 1 month
次要结局
未报告次要终点
研究者
Dr. Peter Jones
Director of RCFFN
University of Manitoba