Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury

Completed

• Conditions: Severe Burn Injury

• Registration Number: NCT00609700
• Lead Sponsor: Klinikum St. Georg gGmbH

Brief Summary

This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.

Detailed Description

In the early period following severe burn injury volume replacement with high amounts of crystalloids is necessary. In this study we compare the organ function scores of a historical patient group, treated with Ringer's Lactate solution, with an actual patient population, treated with Ringer's Acetate solution.

Study Timeline

• Study Start: 2007-12
• Study First Submitted: 2008-01-25
• Study First Submitted QC: 2008-02-06
• Study First Posted: 2008-02-07
• Primary Completion: 2010-11
• Study Completion: 2010-12
• Status Verified: 2011-10
• Last Update Submitted: 2011-10-14
• Last Update Posted: 2011-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• Age >=18 years and <80years
• Burned surface area >20% and <70%
• Burn injury < 24 hours
• Agreement to the study procedures

Exclusion Criteria

• Burned surface area > 70%
• Expected survival time < 24 hours
• Acute or chronic heart failure NYHA III or IV
• Adult respiratory distress syndrome
• Renal failure
• Hepatic failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change of SOFA-score from day 3 to day 7 after severe burn injury	day3, day7, day28, day60

Secondary Outcome Measures

Name	Time	Method
Changes in electrolyte-balance	day3, day7, day28

Trial Locations

Locations (1)

Klinikum St Georg; 🇩🇪 Leipzig, Sachsen, Germany