Acetated Ringer's Solution Versus Saline in Patients With Septic Shock
Overview
- Phase
- Not Applicable
- Intervention
- Fluid resuscitation
- Conditions
- Septic Shock Hyperdynamic
- Sponsor
- Southeast University, China
- Enrollment
- 2000
- Primary Endpoint
- Incidence of major adverse renal events in 28 days
- Last Updated
- 5 years ago
Overview
Brief Summary
The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. The investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.
Detailed Description
Normal saline and Ringer's solutions are the preferred crystalloid fluids administered in early septic shock. However, evidence have associated saline with hyperchloremia and secondary metabolic acidosis, and renal vasoconstriction, increased incidence of acute kidney injury (AKI) and mortality. The primary aim of this trial is to compare the effect of acetated ringer's solution with that of saline for therapy on the incidence and development of major adverse renal events among septic shock patients. The investigators hypothesize that use of acetated ringer's solution for resuscitation among septic shock patients will reduce the incidence of major adverse kidney events.
Investigators
Jingyuan,Xu
Zhongda Hospital,Southeast University, China
Southeast University, China
Eligibility Criteria
Inclusion Criteria
- •Adult patients presenting to the ICU diagnosed as septic shock within 24 hours.
Exclusion Criteria
- •Likely requirement for immediate hemodialysis or renal replacement therapy;
- •Patients have already received fluids for more than 4 liters;
- •Patient in extremis or death deemed imminent and inevitable.
Arms & Interventions
saline group
Use saline for fluid resuscitation during the first 72 hours after enrollment
Intervention: Fluid resuscitation
Acetated Ringer's solution group
Use acetated Ringer's solution for fluid resuscitation during the first 72 hours after enrollment
Intervention: Fluid resuscitation
Outcomes
Primary Outcomes
Incidence of major adverse renal events in 28 days
Time Frame: 28 day
Incidence of major adverse renal events
Secondary Outcomes
- Incidence of kidney injury(28 day)
- Serum creatinine（umol/L）(28 day)