Analgesia in Inguinal Hernia Repair Using a Cyclooxygenase-2-specific Inhibitor
- Conditions
- Adverse Anesthesia Outcome
- Interventions
- Drug: Placebo
- Registration Number
- NCT02884986
- Lead Sponsor
- Bnai Zion Medical Center
- Brief Summary
Acute pain is the result of activating nociceptive pathways in both the peripheral and central nervous system. The origin of most acute pain from surgical stimulation is the mechanical trauma of the local tissue and the subsequent acute inflammatory response.
No studies have investigated the combined use of anti-inflammatory analgesics with spinal anaesthesia/analgesia for pre, intra and postoperative multimodal pain protection in patients undergoing day-case IHR. The aim of the investigators study is therefore to assess the efficacy of preoperative combined administration of etoricoxib and standard spinal anaesthesia in the reduction of postoperative pain following IHR.
- Detailed Description
Acute pain is the result of activating nociceptive pathways in both the peripheral and central nervous system. The origin of most acute pain from surgical stimulation is the mechanical trauma of the local tissue and the subsequent acute inflammatory response. Open inguinal hernia repair is one of the commonest surgical procedures which may provoke pain of variable intensity and duration.
Etoricoxib (Arcoxia®) is a NSAID with anti-inflammatory and analgesic properties mainly achieved via selective peripheral COX-2 inhibition. Spinal anaesthesia using local anaesthetics combined with opioids affects the transmission, modulation and modification stages of nociceptive afferent impulses and its analgesic qualities are superior to local anaesthesia alone.
No studies have investigated the combined use of anti-inflammatory analgesics with spinal anaesthesia/analgesia for pre, intra and postoperative multimodal pain protection in patients undergoing day-case IHR. The aim of the investigators study is therefore to assess the efficacy of preoperative combined administration of etoricoxib and standard spinal anaesthesia in the reduction of postoperative pain following IHR.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- American Society Anesthesiology Class I and II
- Under treatment with Non Steroid Antinflammatory Drug
- Under Opioid treatment
- Peptic ulcer
- Liver insufficiency
- Renal insufficiency
- Asthma
- Cardiovascular disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo 120mg of oral Placebo the same amount as the drug administrated one hour prior to spinal anaesthesia induction Etoricoxib Etoricoxib 120mg of oral Etoricoxib under the brand name Arcoxia® (Merck Sharp \& Dohme) one hour prior to spinal anaesthesia induction
- Primary Outcome Measures
Name Time Method Pain VAS Score Each four hours until 24 hours In the post operative period
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bnai Zion Medical Center
🇮🇱Haifa, Israel