A study to evaluate the effect of Dushivishari Agad tablets orally and Arjuntwak Churna for facepack in the treatment of Melasma.

Phase 3

Not yet recruiting

• Conditions: Chloasma. Ayurveda Condition: VYANGAH,

• Registration Number: CTRI/2025/06/088782
• Lead Sponsor: Dr . Shivali Ajay Nimgale

Brief Summary

Melasma is a hyperpigmentation disorder of skin. It causes hyperpigmented causes on cheeks, chin  upper lips, nose and forehead. Skin is the biggest organ of the body.  Now a days harmful toxins like UV radiation, environmental pollution, use of cosmetics, oral contraceptive pills etc have direct effect on skin  which leads to skin disorders . This toxins get accumulated in the body and causes skin diseases like melasma . It is also called as Chloasma. In contemporary medicine, melasma is treated with use of steroids, skin peeling, chemical peeling, PRP like procedures, which may have many side effects which are yet to be known and are quite expensive for economically poor people.  Ayurveda  treatment is safe, convenient, cheap and easy to use. This study includes use of Dushivishari Agad orally and arjuntwak churna for external application . This are herbal formulations which  includes herbs having  specific properties like anti itching, blood purifying, anti poisonous, skin brightening etc.



Contents of Dushivishari Agad

Piper nigrum ( pippali)

Cybopogon martini (Dhyamak)

Nordostachy jatamansy ( jatamansi)

Symplococus racemosa ( Shaavara)

Cyperus rotundus (Musta )

Tribulus terristris ( Suvarchika)

Pavonia odorata (Toya )

Elitaria cardamomum ( Sukshma ela)

Red ochre ( kanak gairik)



And Arjuntwak churna is the powdered form of skin of Arjun plant bark.

Dushivishari Agad will me given in tablet forms in dose of 500 mg BD and Arjun twak churna will be used as face pack for external application on the affected area for 2 months. 4 Follow ups after every 15 days will be carried out on 15th, 30th, 45th and 60th day. Grade scale which induces grading of skin color, itching, dryness, oiliness, diameter, burning sensation  along with MASI SCALE (Melasma Area and Severity Index)  will be used as a assessment parameter. Before treatment  and After treatment  will me compared and discussion will be made on observations. Conclusion will be drawn on the basis of discussion.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2025-05-31
• Study Start: 2025-06-20

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

pts comimg to Sane Guruji Arogya Kendra having Sign and Symptoms of Vyanga (Melasma) will be selected irrespective of their gender , community, caste and economic status.

Exclusion Criteria

• Patient with present and past history of any skin diseases like psoriais, eczema.
• Pregnant and lactating women .
• Patients having Hyperpigmentation due to Addisons Diseases, cushings Diseases.
• Already Diagnosed Thyroid Diseases.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MASI SCALE	baseline 15th day 30th day 45th day and 60th day
GRADE SCALE	baseline 15th day 30th day 45th day and 60th day
To evaluate the efficacy of Dushivishari Agad orally and Arjun Twak churna lep in the management of Vyanga with special reference to melasma	baseline 15th day 30th day 45th day and 60th day

Secondary Outcome Measures

Name	Time	Method
To observe adverse effect of Dushivishari Agad and Arjunchurna lepa	baseline 15th day 30th day 45th day 60th day

Trial Locations

Locations (1)

Sane Guruji Arogya Kendra Malwadi Hadapsar Pune 411028; 🇮🇳 Pune, MAHARASHTRA, India

Sane Guruji Arogya Kendra Malwadi Hadapsar Pune 411028

🇮🇳Pune, MAHARASHTRA, India

DrShivali Nimgale

Principal investigator

8177898891

shivalinimagle1203@gmail.com